Serenity Cream
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Serenity Cream

Natural PMS Relief

Bioidentical progesterone cream for PMS relief *
Bioidentical progesterone cream for PMS relief *

Serenity Natural Progesterone Cream

For over 20 years Wellsprings Serenity has been chosen by women and doctors as a natural treatment for Premenstrual Syndrome (PMS).

Many women who use Serenity report that their PMS symptoms are relieved and quality of life improved, without the side-effects of some other PMS treatments. *

Effective Symptoms Relief

Wellsprings Serenity can help relieve most PMS symptoms.

These include mood swings, weight gain, anxiety, tiredness, insomnia, bloating, stomach ache, breast tenderness, greasy skin and hair, headaches and changes in sex drive. *

Tried and Tested

Wellsprings Serenity has been helping relieve the symptoms of PMS for thousands of women since 1997.

Natural Progesterone, its active ingredient, has been prescribed since the 1930's for the treatment of hormone imbalance. *

Natural, Bioidentical Hormones

The active ingredient in Wellsprings Serenity is Natural Progesterone which is bioidentical to your body’s own progesterone.

This means better effectiveness and less side effects. *

Long Term Health

The Natural Progesterone in Wellsprings Serenity may help combat the effects of bone breakdown.

This can lead to osteopenia and osteoporosis in later life. *
* Every woman is unique. Your results may vary.

IMPORTANT: Serenity cream is NOT recommended if you're using a contraceptive pill, implant or coil, unless you take additional contraceptive precautions. All three contain synthetic progestins which compete with the same receptor sites in the body as the natural progesterone in Serenity, potentially making them less effective.

What our customers are saying...

TA, London
"Serenity quickly sorted out all these problems and now I feel really great. I can't thank you enough for my new life." *
JH, Northamptonshire
"After so many attempts at trying to improve my PMS, Serenity has been the only proper relief I have had." *
MP, Oxfordshire
"Since using the cream, I can honestly say that my menstrual health and general outlook on life have taken a huge turn for the better." *

* Please note that our customer reviews are individual experiences. Your results may vary.


A Premium Progesterone Cream

Wellsprings Serenity is a gentle, fragrance free, natural progesterone cream with an advanced liposomal formula that optimises absorption.

Certified Bioidentical Progesterone Content

2.34% Natural Progesterone
Each 60g (2.1oz) jar of Serenity contains 1,404mg of bioidentical USP Pharmaceutical grade Natural Progesterone extracted from plant saponins.

Advanced Liposomal Formula

Enhanced Absorption
Serenity’s advanced liposomal formula optimises progesterone absorption while keeping skin looking healthy and moisturised in areas where applied.


All natural ingredients
Free from common allergens.

Fragrance Free

For discreet application
Serenity is fragrance free so as not to interfere with other scented products you may be using.

Animal Friendly

No animal testing
Serenity is not tested on animals in any way and no animal by-products are used in its formulation.


Deionized Water, Caprylic/Capric Triglyceride, Glycerin, Aloe Barbadensis Leaf Juice, Progesterone, Phenoxyethanol, Caprylyl Glycol, Sorbic Acid, Cetyl Alcohol, Glyceryl Stearate, Isopropyl Myristate, Stearic Acid, Sodium, Hyaluronate, Sodium PCA, Methyl Glucose Sesquistearate, Aminomethyl Propanol, Carbomer, Tocopheryl Acetate, Grapefruit Seed Extract, PEG-20 Methyl Glucose Sesquistearate, Xanthan Gum. Manufactured in the USA
A dose of Wellsprings Serenity cream should be applied morning and bedtime to both thin and fatty tissue areas of the body. It is important to massage the cream into a different area each time.

Each recommended dose of cream is 1/8th of a teaspoon (0.5ml). This amount is the size of a garden pea.

We recommend using a double dosage (2 pea-sized amounts of cream, twice a day) for the first month of application. Also, please ensure you finish the full jar or bottle of your cream to allow time for your hormone levels to stabilise and symptoms to be properly treated.

Whether you choose our 60ml jar or 100ml pump bottle, the doseage is exactly the same. To dispense a pea-sized amount from the pump bottle, gently press the pump until the correct amount is dispensed.*

Usage Schedule *
* Typical usage for best performance based on experience of long-term users of Serenity. Your results may vary.

Usage Overview

A healthy woman will naturally manufacture 20-25mg of progesterone per day in the second half of her monthly cycle and the intention is to deliver this same amount of bioidentical progesterone into the system via the cream.

Each dose of Serenity contains 12mg of bioidentical progesterone, so one application in the morning and one at bedtime will constitute a dosage of 24mg per day, delivering approximately the same as would be produced naturally.

If symptoms are severe you may use a double dose mornings and evenings, but all women are different and dosage should be assessed and modified by each individual through their own experience over a period of time.

Each 60ml jar contains 120 doses, so a jar will last around 4 months for those on the pre-menopausal regime and 2.5 months for those on the 24 day menopausal regime.*

Applying Cream

Serenity should be applied to both thin and fatty tissue areas of the body.

The best application areas are: the face, neck, inside of the upper arms, lower back or inner thighs for thin skinned areas and buttocks, lower arms, outer thighs and stomach for fatty areas.

Top Tip

How to measure a single dose
Simply dab the underside of your little finger halfway to the nail if using a jar, or gently press the pump if using our pump bottle. The amount should be about the size of a garden pea.

Top Tip

Quick Relief
For a more instant effect (for migraine headaches for example) it has been found that massaging a little extra cream into the areas of thin skin (inner wrists, temples and behind the ears) may give relief.
* Every woman is unique. Your results may vary
PMS encompasses a huge range of symptoms - and potential treatments. But some treatments are more successful than others.
Based on the foundation of enhancing natural progesterone, this 3 step plan could be a complete solution for PMS problems
Hear what doctors have to say about natural progesterone and its benefits
Based on the foundation of enhancing natural progesterone, this 3 step plan could be a complete solution for PMS problems