Twenty to
One Cream
Natural Menopause Relief
Bioidentical combination cream for the relief of hot flushes, weight gain and other symptoms of menopause
Each bottle lasts 4+ months
Wellsprings Twenty to One combination cream is a natural alternative to Hormone Replacement Therapy (HRT) for women deficient in progesterone and oestrogen.
Some menopausal women may find that they are unable to completely eliminate hot flushes, mood swings or vaginal dryness using a bioidentical progesterone cream like Wellsprings Serenity, so an additional small amount of oestrogen is required.
Wellsprings Twenty to One cream (also known as '20-1') contains bioidentical progesterone and oestrogen in a ratio of 20 to 1, hence the name. *
Some menopausal women may find that they are unable to completely eliminate hot flushes, mood swings or vaginal dryness using a bioidentical progesterone cream like Wellsprings Serenity, so an additional small amount of oestrogen is required.
Wellsprings Twenty to One cream (also known as '20-1') contains bioidentical progesterone and oestrogen in a ratio of 20 to 1, hence the name. *
Wellsprings Twenty to One combination cream is a natural alternative to Hormone Replacement Therapy (HRT) for women deficient in progesterone and oestrogen.
Some menopausal women may find that they are unable to completely eliminate hot flushes, mood swings or vaginal dryness using a bioidentical progesterone cream like Wellsprings Serenity, so an additional small amount of oestrogen is required.
Wellsprings Twenty to One cream (also known as '20-1') contains bioidentical progesterone and oestrogen in a ratio of 20 to 1, hence the name. *
Some menopausal women may find that they are unable to completely eliminate hot flushes, mood swings or vaginal dryness using a bioidentical progesterone cream like Wellsprings Serenity, so an additional small amount of oestrogen is required.
Wellsprings Twenty to One cream (also known as '20-1') contains bioidentical progesterone and oestrogen in a ratio of 20 to 1, hence the name. *
Effective Menopause Symptom Relief
Including hot flushes, night sweats, IBS, bloating, breast tenderness, low libido, vaginal dryness, mood problems, insomnia, headaches, hair loss and dry skin*
Natural, Bioidentical Hormones
The active ingredients in Wellsprings Twenty to One are bioidentical progesterone and oestrogen which are identical to your body’s own hormones. *
Tried and Tested
Wellsprings' creams have been helping relieve the symptoms of menopause for thousands of women since 1997. *
Why a Cream?
In pill form bioidentical hormones can be filtered out by the liver, so Twenty to One is a hyper-liposomal cream which optimises progesterone and oestrogen absorption and maximises symptom relief.
What doctors say about Wellsprings
Dr Tony Coope
MB; ChB; DObstRCOG
MB; ChB; DObstRCOG
"Wellsprings have the required knowledge, integrity and quality products to improve the health and hormonal balance of women along their whole 'continuum of vulnerability' from puberty to post-menopause."
Dr B Peatfield
DCmdrSOStj MB BS LRCP MRCS
DCmdrSOStj MB BS LRCP MRCS
"I have been using natural progesterone cream for some years now... both my patients and I have, without exception, been delighted with its efficacy."
What our customers say about Twenty to One combination cream
Lynda, London
"After a couple of months on 20-1 cream I'm a different person. I am nearly a stone lighter, the hot sweats have all but gone and I can now get on with my life" *
Jacqui, Bedford
"After using Wellsprings 20-1 for one week the hot flushes eased. You have saved my life and my relationship with my children and partner. I can't rave enough about this product" *
* Please note that our customer reviews are individual experiences. Your results may vary.
What the science says about natural progesterone
There is a large amount of high quality scientific research showing that bioidentical progesterone can relieve menopause symptoms and promote general health in women. It has also been shown to be safer than the synthetic progestins used in common HRT treatments.
"Bioidentical hormone preparations have demonstrated effectiveness in addressing menopausal symptoms... The studies reviewed suggest bioidentical progesterone does not have a negative effect on blood lipids or vasculature as do many synthetic progestins."
"[progesterone] has been shown to relieve menopausal symptoms and improve sleep without affecting cognition, blood lipids or cardiovascular risk factors. It may also reduce bone loss and maintain skin elasticity"
"[transdermal progesterone and estrogen] are a safe and well-tolerated option to treat menopausal symptoms, with a better benefit risk profile compared to synthetic gestagens"
The Formula
Wellsprings Twenty to One contains plant-derived bioidentical progesterone and oestrogen in an advanced liposomal cream.
Available in a 60ml jar or 100ml pump bottle.
Each 0.5ml dose of cream delivers:
| Bioidentical Progesterone | 12mg |
| Bioidentical Oestrogen (Estriol and Estradiol) | 0.6mg |
Show Full Ingredients...
Ingredients:
Deionized Water, Aloe Barbadensis Leaf Juice, Soybean Oil, Progesterone (2.34%), Glycerin, Glyceryl Stearate SE, Isopropyl Myristate , Phenoxyethanol, Caprylyl Glycol , Sorbic Acid, Cetyl Alcohol, Methyl Glucose Sesquistearate, Stearic Acid, Sodium PCA, Sodium, Hyaluronate, Tocopheryl Acetate, Carbomer, PEG-20 Methyl Glucose Sesquistearate, Grapefruit Seed Extract, Xanthan Gum, Estriol (0.11%), Aminomethylpropanol, Estradiol (0.01%).
Hypo-Allergenic
Free from common allergens.
Fragrance Free
Twenty to One is fragrance free for discreet application.
Animal Friendly
Twenty to One is not tested on animals in any way and no animal by-products are used in its formulation.
How to Use Wellsprings Twenty to One Cream
Two doses of cream should be applied to the body daily, one in the morning and one in the evening. Each dose of cream is 1/8th of a teaspoon (0.5ml). Simply dab the underside of your little finger halfway to the nail if using a jar, or gently press the pump if using our pump bottle. The amount should be about the size of a garden pea.
The cream should be applied to thin tissue areas of the body, rotating between different areas each day. The best application areas are the inside of the lower and upper arms, the inner thighs and the sides of the abdomen.
Depending on where you are in your hormonal journey you will need to take short breaks from application each month to maintain the sensitivity and optimal absorption of the hormone receptors.
Pre-Menopause (still having regular periods)
Counting day one of your period as the start of the four week application cycle, take a two week break then apply the cream twice daily in the 3rd and 4th weeks of the cycle. Repeat this 4 week cycle.
Peri-Menopause (having irregular periods approaching menopause age)
Follow the guidance below for Menopause/post-menopause but if a bleed occurs at any point within the three week application period pause the cream for 1 week and then start a completely new 3 week period of application.
Menopausal, Post-Menopause or Post-Hysterectomy (no longer having periods)
Apply the cream twice daily for 3 weeks, pause application for 1 week. Repeat this 4 week cycle.
If you're new to Wellsprings...
Whichever application regime you're using we recommend that new customers use a double dosage (2 pea-sized amounts of cream, twice a day) for the first month of application. Also, please ensure you finish the full jar or pump bottle of your cream to allow time for your hormone levels to stabilise and symptoms to be properly treated.
The Formula
Wellsprings Twenty to One contains plant-derived bioidentical progesterone and oestrogen in an advanced liposomal cream.
Available in a 60ml jar or 100ml pump bottle.
Each 0.5ml dose of cream delivers:
| Bioidentical Progesterone | 12mg |
| Bioidentical Oestrogen (Estriol and Estradiol) | 0.6mg |
Show Full Ingredients...
Ingredients:
Deionized Water, Aloe Barbadensis Leaf Juice, Soybean Oil, Progesterone (2.34%), Glycerin, Glyceryl Stearate SE, Isopropyl Myristate , Phenoxyethanol, Caprylyl Glycol , Sorbic Acid, Cetyl Alcohol, Methyl Glucose Sesquistearate, Stearic Acid, Sodium PCA, Sodium, Hyaluronate, Tocopheryl Acetate, Carbomer, PEG-20 Methyl Glucose Sesquistearate, Grapefruit Seed Extract, Xanthan Gum, Estriol (0.11%), Aminomethylpropanol, Estradiol (0.01%).
Hypo-Allergenic
Free from common allergens.
Fragrance Free
Twenty to One is fragrance free for discreet application.
Animal Friendly
Twenty to One is not tested on animals in any way and no animal by-products are used in its formulation.
Is Twenty to One Right For Me?
Twenty to One cream is our most popular cream for menopausal women who require a small amount of oestogen alongside progesterone.
But we have created a selection of bioidentical hormone creams for every stage of a woman's hormonal journey. Click here to see our full range of creams.
You can also email our hormone experts at support@wellsprings-health.com for free, friendly help.
All information given on this site is for general interest only. Every woman is unique. Your results may vary.
Disclaimer: This website is intended to educate visitors about Wellsprings products and does not constitute or replace medical advice.For medical advice you should always talk to a healthcare professional.
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